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Author

D. Schneider

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Open access Oct 2026

Structure and activity of the giant RNA polymerase ejected from Pseudomonas phage DEV.

A hallmark of Schitoviridae bacteriophages is a giant (∼3,500-residue) virion-associated RNA polymerase (vRNAP) that is ejected into the host to initiate early transcription. Structural and functional characterization of vRNAP has thus far been limited to coliphage N4, leaving the conservation of vRNAP architecture, pr...

Nathan F. Bellis, R. Lokareddy, James M. Scherer et al. · 0 citations
Open access Sep 2026

TFIIS enhancement of Pol II cleavage is under kinetic control

Abstract The eukaryotic RNA polymerases (Pols) contain subunits or interact with trans-acting factors that confer robust endonuclease activity. A12.2 and C11 are subunits of Pol I and Pol III, respectively. Pol II, however, recruits transcription factor IIS (TFIIS). This evolutionary divergence of A12.2 and C11 being b...

Ryan M. Requijo, N. K. Maluf, D. Schneider et al. · 0 citations

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