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Sep 2026

Physicochemical interactions between oral drug products: An integrated in vitro and PBPK modeling approach.

While pharmacodynamic and pharmacokinetic drug-drug interactions are well established, physicochemical interactions between co-administered oral drug products and their impact on drug absorption remain poorly understood. This study combined biorelevant in vitro testing and physiologically based pharmacokinetic (PBPK) m...

Christopher Hauß, Denise Feick, D. Selzer et al. · 0 citations
Open access Oct 2026

The SafePolyMed Medication Management Center

Abstract Polypharmacy is a major risk factor for adverse drug events (ADEs), particularly when drug-drug and drug- gene interactions are insufficiently considered in routine care. The EU-funded SafePolyMed project addresses this challenge by developing a digital Medication Management Center (MMC) that integrates pharma...

Sabine C. Gepp, F. Schera, F. Marok et al. · 0 citations

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