Blocking the gut-liver IgA axis attenuates macrophage-mediated inflammation and injury in alcohol-associated liver disease.
BACKGROUND Alcohol-associated liver disease (ALD) is a major cause of morbidity, yet therapies for severe inflammation remain limited. OBJECTIVE We examined whether circulating and hepatic immunoglobulin A (IgA) and hepatic myeloid-cell IgA binding are associated with interleukin-1 beta (IL-1β)-linked inflammation an...