Targeting α5-GABAA receptors to restore dopamine system function in a translationally relevant model of perimenopausal psychosis.
BACKGROUND Perimenopause marks a high-risk period for psychiatric instability, often precipitating or exacerbating disorders like schizophrenia. While traditional antipsychotics can be effective, they often worsen vasomotor symptoms and carry side effects that drive high discontinuation rates. We hypothesized that hipp...