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D. Shechner

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Review Open access Aug 2026

Mapping subcellular microenvironments using oligonucleotide-directed proximity-labeling

Understanding how cells compartmentalize their biomolecules into discrete structures remains one of the fundamental goals of cell biology. The proliferation of proximity-labeling (PL) technologies has been invaluable toward this goal, enabling biochemical “dissection” of compartments that would be intractable to classi...

Scott A. Schactler, Nicholas G Skiados, Amol A Gajendragadkar et al. · 0 citations
Open access Aug 2026

A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites

The development of Organelle Contact-dependent Affinity Purification (ORCA) is established as a broadly applicable approach for investigating the spatial organization of intracellular organelles and reveal organelle contacts as key determinants of mitochondrial specialization.

G. M. Otto, Akimi Green, Jennifer Cabarrús et al. · 0 citations

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