Author

D. Spetzler

2 papers indexed here

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Clinical trial Open access Oct 2026

The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial

Phosphatidylinositol 3-kinase delta (PI3Kδ) promotes tumour cell growth directly or indirectly by activating immune-suppressive cells. In contrast to previous PI3Kδ inhibitors, roginolisib is a selective, non-ATP competitive inhibitor, which locks PI3Kδ into an inactive state and causes an allosteric modulation. In a F...

A. D. Di Giacomo, M. Simonelli, A. Losurdo et al. · Nature Communications · 2 citations

Preprint Sep 2026

HERO: Histology Encoder for Robust Representation in Oncology

Foundation models trained on large pathology image corpora now provide strong, transferable representations for computational pathology. Over the past few years a series of such models has been released, each trained on more slides than the last; on standard classification and segmentation benchmarks, the leading model...

Zhi Li, E. Amidi, Ya-Ting Cheng et al. · 0 citations