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Author

D. Sprengers

2 papers indexed here

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Open access Sep 2026

NKG2A-HLA-E axis contributes to an immunosuppressive checkpoint network in hepatocellular carcinoma

Abstract Background The immunosuppressive tumor microenvironment in hepatocellular carcinoma (HCC) limits the efficacy of current immunotherapies. The interplay between the emerging inhibitory receptor NKG2A and its activating counterpart NKG2C, both binding HLA-E, and its interaction with the PD-1-PD-L1 pathway in can...

Yan Li, Xiao-Mei Zhuang, Yi-Sen Tang et al. · 0 citations
Open access Sep 2026

Comparative performance of HCC risk scores in identifying low-risk patients with cirrhosis: A multicenter cohort study.

BACKGROUND & AIMS The rising prevalence of cirrhosis, driven by non-viral etiologies, strains healthcare systems and necessitates personalized hepatocellular carcinoma (HCC) surveillance. We conducted a head-to-head comparison of the Toronto HCC risk index (THRI) and aMAP score within an etiology-diverse Western popula...

Mohamed Moussa, K. de Wit, L. Baak et al. · 0 citations

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