Author

D. Tran

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Open access Aug 2026

ADP-Bound States of Cytoplasmic Dynein: Cryo-electron Microscopy Reveals a Two-Step Post-Power-Stroke Transition and Roles of Regulatory ATPase Sites.

These findings provide a mechanistic model in which coordinated conformational dynamics across multiple ATPase sites govern dynein's chemomechanical cycle and suggest a dynamic equilibrium between two ADP-bound states.

Hiroshi Imai, R. Kanazawa, Toshihisa Maeshima et al. · Journal of Molecular Biology · 0 citations

Open access Jul 2026

Mechanistic insight into signal bias by the agonist-dependent conformational dynamics of GPR84

GPR84 is an orphan class A GPCR primarily expressed in immune cells, where it plays key roles in inflammation and metabolism. Here, we present the cryo-electron microscopy structures of the GPR84-Gi complex bound to the G protein–biased agonist DL-175, and the inactive state of GPR84 bound to the antagonist GLPG1205. C...

Shota Suzuki, D. Tran, Kouki Nishikawa et al. · Nature Communications · 0 citations