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Author

D. V. Von Hoff

2 papers indexed here

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Sep 2026

Abstract B144: MUC16-directed DR5 activation by IMV-M induces selective tumor cell apoptosis and tumor regression and enhances the activity of KRAS inhibitors in preclinical pancreatic cancer models

Bispecific apoptosis triggers (BATs) are a novel class of bispecific antibodies designed to target both a tumor-associated antigen and death receptor 5 (DR5) that have shown improved efficacy and reduced toxicity compared to conventional DR5 antibody therapeutics in preclinical models. IMV-M is a novel bivalent BAT t...

Hai-Yong Han, M. Zucker, Sanjana Tripuraneni et al. · 0 citations
Sep 2026

Abstract A078: Predictive Biomarkers for Malignant Progression of Pancreatic Intraductal Papillary Mucinous Neoplasms

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of human cancers and the third leading cause of cancer-related deaths in the US. Pancreatic tumorigenesis is often linked to malignant transformation of mucinous pancreatic cystic lesions (PCL’s), comprised mostly of Intraductal Papillary Mucinous N...

K. Chougoni, Cynthia M. Quintero, Kurtis Liang et al. · 0 citations

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