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Author

David J. VanderWeele

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Open access Oct 2026

Attenuating NKG2D stimulation reshapes intratumoral NK cell functional state to enhance persistence and anti-tumor efficacy.

NK cell-based therapies for solid tumors are limited by poor persistence and progressive functional impairment. Here, we investigated how the strength of NKG2D stimulation shapes NK cell fate and therapeutic efficacy. Using B10G5, a MICA/B-targeting partial agonist antibody that attenuates NKG2D stimulation, we show th...

Si-Zhe Liu, Ryan J. Brown, Payal Dhar et al. · 0 citations
Open access Sep 2026

Clinical and Molecular Profiles of Treatment-Emergent Small Cell Neuroendocrine Prostate Cancers in the Era of Intensified Systemic Therapies.

Variant histologic features can emerge in therapy-resistant prostate cancers, with treatment-emergent small-cell neuroendocrine carcinomas (t-SCNC) the most common. Here we report clinical, histopathological, and genomic features of 126 t-SCNCs and 14 other treatment-emergent variant histologies. This retrospective mul...

Nadeem Bilani, Jesenia M. Perez, Ana M. Aparicio et al. · 0 citations

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