D. Yon

Adherence to the 24 h Movement Guidelines and Associated Factors Among First-Year University Students in Spain: UNILIFE-M Study at Universidad Loyola Andalucía

Highlights What are the main findings? Only 21.2% of first-year students at this Spanish university (137/646 with complete guideline data) met all three 24 h movement guidelines for physical activity, sedentary behavior (total sitting and recreational screen time), and sleep, and 8.4% met none. In multivariable analyse...

Sociodemographic and Anthropometric Determinants of Body Dissatisfaction in a Sample of Spanish Adolescents: The EHDLA Study

Body dissatisfaction is prevalent among adolescents and linked to adverse outcomes. This study examined sociodemographic and anthropometric factors associated with body dissatisfaction in Spanish adolescents. Cross-sectional data from the Eating Healthy and Daily Life Activities (EHDLA) study (N = 1378 students aged 12...

Social Patterning of 24-Hour Movement Behaviors Among Spanish Adolescents: Cross-Sectional Accelerometry Evidence from the EHDLA Study

Conurrent adherence to 24HMB guidelines is critically low and socially patterned, and future 24HMB surveillance should use validated, standardized, and clearly reported protocols, and cross-study comparisons should account for methodological differences in sleep assessment.

Maternal opioid prescriptions and subsequent risk of hospital admission in offspring in South Korea: A nationwide birth cohort study

Background Prenatal opioid exposure may disrupt infant development and immune system function, potentially increasing long-term susceptibility to hospital admissions. Thus, we aimed to investigate the association between prenatal opioid exposure and the risk of hospital admission in children. Methods and findings We es...

Comparative effectiveness of pioglitazone and sitagliptin added to metformin and sulfonylurea in patients with type 2 diabetes

Dipeptidyl peptidase-4 inhibitors and thiazolidinediones are commonly used as add-ons in type 2 diabetes mellitus (T2DM) treatment, but comparative data are limited. This study emulated a target trial to compare sitagliptin and pioglitazone in patients on metformin and sulfonylurea, focusing on changes in glycemic cont...

Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.

OBJECTIVES Early prediction of treatment course in pediatric Crohn's disease (CD) remains limited despite the importance of timely biologic therapy. We developed and externally validated a multimodal model integrating colonoscopy images and clinical data to predict infliximab initiation within 6 months after convention...

Pharmacovigilance signals and regional burden of antibiotic-associated Clostridioides difficile infection: a pharmacovigilance study and Global Burden of Disease Study 2023.

BACKGROUND Despite the substantial global burden of Clostridioides difficile infection (CDI) and its close relationship with antibiotic exposure, evidence characterizing drug- and age-specific risk patterns remains limited. OBJECTIVES This study aimed to characterize antibiotic-associated CDI by assessing drug- and a...

Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring

Importance Evidence on maternal influenza infection during pregnancy and offspring neuropsychiatric risk remains inconsistent and limited by methodologic concerns. Objective To evaluate the association of maternal influenza infection during pregnancy and offspring neuropsychiatric risk. Design, Setting, and Participant...

Clinical Learning-Curve Evidence and Experience-Related Temporal Trends of Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients with Trauma: A Systematic Review

Background/Objectives: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technically demanding, low-frequency intervention that requires both operator proficiency and coordinated trauma-system performance. We systematically reviewed direct clinical evidence on REBOA learning curves and indirect exp...

Decoding the drivers of Alzheimer's disease and other dementias mortality in Asia, 1990-2023: a Global Burden of Diseases Study 2023.

Dementia prevention should be aligned with local cardiometabolic, tobacco, and air-pollution risk profiles, while future studies should assess whether reducing these exposures translates into lower ADOD mortality.

Regional and national burden of attention-deficit hyperactivity disorder in Asia, 1990-2023: a Global Burden of Disease Study 2023.

Home food preparation involvement and ultra-processed food consumption in adolescents: the EHDLA study.

In this secondary cross-sectional analysis of 847 Spanish adolescents (aged 12-17 years) from the Eating Healthy and Daily Life Activities (EHDLA) study, we investigated whether frequency of helping with dinner preparation and grocery shopping (<3 or ≥3 times/week) were associated with ultra-processed food (UPF) consum...