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Review Oct 2026

The evolution of immunotherapy resistance in mismatch repair-deficient colorectal cancer: A spatiotemporal perspective.

Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape for mismatch repair deficient (dMMR) colorectal cancer; however, primary and acquired resistance remain significant challenges in clinical practice. This review proposes a working hypothesis that resistance can be conceptualized as following...

Yuan-Hao Lv, Yuang Ding, Zi-Wei Zhao et al. · 0 citations
Review Open access Oct 2026

Progress in research on gut microbiota regulation of tumorigenesis, progression, and therapeutic response via inflammatory cytokines

Current evidence on how the gut microbiota and inflammatory cytokines jointly regulate tumour development and therapeutic outcomes is summarized and therapeutic strategies that target microbial composition and inflammatory signalling are discussed.

Yan Liu, D. Zang, Jun Chen · 0 citations

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