Author

D. Zong

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Open access Oct 2026

HSP90AA1 induces M2 macrophage polarization via stabilizing ITGB1 and promoting CCL2 secretion in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) presents a major treatment challenge, largely due to immunotherapy resistance. The molecular mechanisms that drive the remodeling of the immunosuppressive tumor microenvironment (TME) in NPC are still not well understood. This study explored how heat shock protein 90 alpha family class...

Ming-Jun Ding, Chun-Sheng Wang, Xiang Cao et al. · Scientific Reports · 0 citations

Open access Oct 2026

Case Report: Low-dose radiotherapy as part of multimodal salvage therapy for immunotherapy-resistant SMARCA4-deficient non‐small cell lung cancer

SMARCA4-deficient non-small cell lung cancer (SD-NSCLC) is a highly aggressive molecular subtype. This malignancy is often diagnosed at an advanced stage, carrying a dismal prognosis and also demonstrating poor responsiveness to traditional treatment. Beyond its primary site, the disease can exhibit unusual metastatic...

T. Bu, Nan Zhang, T. Jin et al. · Frontiers in Oncology · 0 citations

Open access Aug 2026

PCSK9 as a Key Gene of Metastasis in Lung Adenocarcinoma: A Multi-omics and Experimental Validation Study.

BACKGROUND Lung adenocarcinoma (LUAD) is the most common form of lung cancer. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is abnormally expressed in various tumor tissues and is associated with malignant phenotypes. However, the clinical significance, function, and mechanism of LUAD invasion and metastasis re...

D. Zong, De-Jun Wang, L. Qian et al. · Frontiers in Bioscience · 0 citations