Phosphorylation of the mitochondrial calcium uniporter beta subunit matrix domain locks a conformation that suppresses mitochondrial calcium flux.
Mitochondrial calcium (Ca2+) uptake is a central regulator of metabolism, signal transduction and cell death pathways. The mitochondrial calcium uniporter complex (mtCU) mediates this flux through a tetrameric pore comprised of MCU and MCU beta (MCUb) subunits. The large, matrix-oriented amino (N)-terminal domains (NTD...