Conventional metal-based contrast agents for magnetic resonance imaging (MRI) present concerns regarding potential chronic toxicity with prolonged use and inherently lack therapeutic functionality. Integrating the antioxidant 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), which possesses intrinsic paramagnetic propertie...
Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticles (DOX@MSN) embedded within chitosan microsphere...
Qiuchen Luo, Shuao Dong, Jiaxin Wang et al.· ACS Applied Materials and In...· 0 citations
Synergistic photodynamic and photothermal therapy (PDT/PTT) holds immense promise for cancer treatment, yet its efficacy is often compromised by limited photosensitizer performance, glutathione (GSH)-mediated ROS quenching, and tumor-protective autophagy. Herein, we developed a GSH-responsive hydrophilic porphyrin copo...
Yadong Liu, Yifan Xue, Hongru Lin et al.· Acta Biomaterialia· 0 citations
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