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Open access Oct 2026

Sinensetin ameliorates osteoarthritis progression by modulating the NF-κB/NLRP3 signaling pathway and suppressing chondrocyte pyroptosis

Sinensetin (SIN) is a natural flavonoid with potential anti-inflammatory effects. This study investigated whether SIN ameliorates osteoarthritis (OA) and explored its underlying mechanisms. In vitro, SIN (0.05-1 ug/mL) protected human OA chondrocytes from IL- 1p-induced viability loss. Transcriptome sequencing and mole...

Xuan Jiang, Jia-Nan Xu, Hong-Hou He et al. · 0 citations

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