Author

Da-Wei Zhang

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Review Open access Sep 2026

Mitochondrial dysfunction and PANoptosis-related signaling in acute central nervous system injuries: mechanistic convergence and therapeutic opportunities

Acute central nervous system (CNS) injuries comprise a heterogeneous group of disorders caused by vascular or traumatic factors, including ischemic stroke, intracerebral hemorrhage (ICH), traumatic brain injury (TBI), and spinal cord injury (SCI). These injuries initiate secondary cascades that combine metabolic failur...

Hong-Bo Zhang, Ruo-Xin Tu, Da-Wei Zhang et al. · Frontiers in Molecular Neuro... · 0 citations

Open access Jul 2026

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

KZL-064 is identified, a 2-trifluoromethyl-4-aminoquinazoline derivative, which markedly inhibits HCC cell proliferation, migration, and invasion, induces apoptosis and G2/M arrest, and oral administration achieves tumor suppression comparable to that of sorafenib without significant toxicity.

Shi-Mei Wang, Xudong Cui, Gang Yu et al. · iScience · 0 citations