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Author

Da-Wen Zhao

2 papers indexed here

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Open access Aug 2026

Cancer-intrinsic SIRPα Signaling Triggers Mitochondrial Fission and Immune Tolerance to Promote TNBC Breast-to-Brain Metastasis.

BACKGROUND Triple negative breast cancer (require) new treatment strategies due to poor responses to current therapies. While myeloid SIRPα mediates immunosuppression, its cancer intrinsic role remains poorly understood. METHODS Human breast cancer scRNAseq profiles were used to examine SIRPα expression across differ...

Yu-Ting Tsai, Jessica D. Mackert, Adam S. Wilson et al. · 0 citations
Open access Sep 2026

Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction–associated steatohepatitis

Despite metabolic dysfunction–associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH. Evidence from preclinical and clinical studies suggests that inflammatory polarization of Kupffer cells (KCs) and infiltration of monocyte-derived macrophages...

Kai-Ge Chen, Lu-Lu Wang, Liang Liu et al. · 0 citations

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