Metastatic breast cancer remains a major therapeutic challenge due to the limited efficacy of current treatments against both primary tumors and distant metastases. Here, we developed an arginine-based click-crosslinked nanoplatform for the co-delivery of camptothecin (CPT) and STAT3 siRNA (siSTAT3). The nanoplatform w...
Su-Bin Xiong, Jing-Heng Xiang, Xiao He et al.· International journal of pha...· 0 citations
A novel enzyme-free and label-free fluorescent biosensor based on a cascade signal amplification strategy, integrating an entropy-driven DNA circuit (EDC) with catalytic hairpin assembly (CHA) that offers a promising platform for food safety supervision and clinical diagnostics.
A novel triple-modal biosensor integrating hybridization chain reaction (HCR) with CRISPR/Cas12a was developed for sensitive and selective detection of kanamycin (KANA) and bisphenol A (BPA). The system employs a phosphorothioate-modified G-rich hairpin (SHG4-2) as a dual-functional reporter probe, which resists Cas12a...
Xiao-Long Li, Da-Xiu Li, Yan-Ni Wang et al.· Analytical Methods· 1 citation
In vitro and in vivo evaluations confirm that R-A/G@Z effectively suppresses aggressive breast tumors while maintaining a good safety profile, offering a promising strategy for intelligent metabolic-chemodynamic cancer nanomedicine.
Nian-Ting Xiao, Xiao He, Da-Xiu Li et al.· Journal of Colloid and Inter...· 0 citations
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