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Author

Da-Xiu Li

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Sep 2026

Click-crosslinked arginine-based nanoplatform for co-delivery of camptothecin and siSTAT3 for metastatic breast cancer therapy.

Metastatic breast cancer remains a major therapeutic challenge due to the limited efficacy of current treatments against both primary tumors and distant metastases. Here, we developed an arginine-based click-crosslinked nanoplatform for the co-delivery of camptothecin (CPT) and STAT3 siRNA (siSTAT3). The nanoplatform w...

Su-Bin Xiong, Jing-Heng Xiang, Xiao He et al. · 0 citations
Aug 2026

Label-free and enzyme-free fluorescent biosensor for ultrasensitive detection of tobramycin via cascade signal amplification.

A novel enzyme-free and label-free fluorescent biosensor based on a cascade signal amplification strategy, integrating an entropy-driven DNA circuit (EDC) with catalytic hairpin assembly (CHA) that offers a promising platform for food safety supervision and clinical diagnostics.

Yan-Ni Wang, Yi-Ke Tang, Xin-Tong Wu et al. · 0 citations
Aug 2026

HCR-assisted CRISPR/Cas12a platform enables logic-gate and multimodal detection of kanamycin and bisphenol A.

A novel triple-modal biosensor integrating hybridization chain reaction (HCR) with CRISPR/Cas12a was developed for sensitive and selective detection of kanamycin (KANA) and bisphenol A (BPA). The system employs a phosphorothioate-modified G-rich hairpin (SHG4-2) as a dual-functional reporter probe, which resists Cas12a...

Xiao-Long Li, Da-Xiu Li, Yan-Ni Wang et al. · 1 citation
Aug 2026

Cascade-responsive biomimetic nanoparticles remodel tumor metabolism and potentiate ferroptosis for synergistic therapy of aggressive breast cancer.

In vitro and in vivo evaluations confirm that R-A/G@Z effectively suppresses aggressive breast tumors while maintaining a good safety profile, offering a promising strategy for intelligent metabolic-chemodynamic cancer nanomedicine.

Nian-Ting Xiao, Xiao He, Da-Xiu Li et al. · 0 citations

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