Dai-Chao Wu

Structural basis for T-cell receptor recognition of p53Y220D, a human cancer neoantigen.

Adoptive cell therapy (ACT) with tumor-specific T cells can mediate durable cancer regression. The main target of tumor-specific T cells are neoantigens resulting from mutations in self-antigens over the course of malignant transformation. To understand T-cell recognition of cancer neoantigens at the atomic level, we s...