Amplification-free colorimetric detection of exosomal miRNA using a CRISPR/Cas13a-activated HRP/Au/MoS2 nanobiohybrid catalyst
CRISPR-based, amplification-free colorimetric sensing has emerged as a powerful approach for exosomal miRNA (Exo-miR) analysis, offering high specificity, simple operation, and direct visual readout suitable for point-of-care diagnostics. However, the sensitivity of existing systems is limited because conventional colo...