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Daiya Nemoto

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Open access Sep 2026

Tcf4 CTG Repeat Expansion Induces RNA Toxicity and MBNL-Associated Splicing Dysregulation in a Mouse Model of Fuchs Endothelial Corneal Dystrophy

Purpose To determine whether a Tcf4 CTG repeat knock-in mouse model of Fuchs endothelial corneal dystrophy (FECD) recapitulates molecular features of repeat RNA toxicity and MBNL-associated splicing dysregulation in corneal endothelial cells in vivo. Methods Corneal endothelial tissues from 20-, 40-, and 60-week-old wi...

Taichi Yuasa, Hayato Tsutsumi, N. Ueda et al. · 0 citations

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