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Author

Dan-Dan Liu

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Open access Oct 2026

Improving the Diagnostic Accuracy of Plasma Alzheimer's Disease Biomarkers With Objective and Subjective Cognitive Screening

ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined w...

Maryam Abdolmaleki, Leslie S. Gaynor, Dan-Dan Liu et al. · 2 citations
Open access Oct 2026

Lower cardiac output is associated with longitudinal decreases in cerebrospinal fluid amyloid-β42, a core Alzheimer's disease biomarker, in women but not men.

Subclinical reductions in cardiac output relate to cognitive decline. We examined the relationship between cardiac output and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease pathologies in 153 participants from the Vanderbilt Memory and Aging Project. Linear regression and linear mixed effects regression mo...

Amalia J. Peterson, Yun-Yi Sun, Dan-Dan Liu et al. · 0 citations
#small language model Open access Sep 2026

Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years

ASL-sCoV may serve as an important hemodynamic measure for identifying perfusion deficits tied to SVD burden and progression and could provide substantial insight into the longitudinal clinical consequences of SVD.

W. Robb, Ava M. Santner, Pan-Pan Zhang et al. · 0 citations
Open access Jul 2026

A comparative evaluation of multiple enlarged perivascular space segmentation tools.

DORES provides a multimodal nnU-Net-based pipeline for ePVS segmentation in older adults and demonstrates robust within-cohort performance and reasonable external validity, though scanner-related effects limit application across sites.

James D. LeFevre, W. Robb, Dan-Dan Liu et al. · 0 citations

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