Author

Dan Liu

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Aug 2026

XunZi, an AI biologist, reveals disease-modifying targets.

In Parkinson's disease (PD), where complex mechanisms and limited targets hamper therapy development, XunZi identifies aberrant activation of CHK2 and IRAK4 kinases across multiple models and establishes a paradigm-shifting framework to translate fragmented biomedical knowledge and data into actionable therapeutics.

Xinhe Huang, Junhong Qin, Fei Tang et al. · Nature Biomedical Engineerin... · 0 citations

Open access Aug 2026

3Dloop-FPSSM: Predicting Protein–Protein Interactions by Fusing 3D Local Optimal Oriented Pattern and Folded Position-Specific Scoring Matrix

This study introduces a novel sequence-based framework for PPI prediction, which combines position-specific scoring matrices (PSSMs), 3D local optimal orientation patterns (3Dloop), and histogram gradient boosting (HistGB) and shows that the approach provides a reliable and efficient solution for PPI prediction.

Fangfang Bai, Dan Liu, Guangxian Wang et al. · Algorithms · 0 citations