LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD.
It is shown that homocysteine accumulation in proximal tubular epithelial cells (PTECs) is a significant contributor to mitochondrial oxidative stress in DKD and the role of the lncPTEC/MTHFD1 axis in Hcy-mediated mitochondrial oxidative stress is elucidated, offering potential diagnostic biomarkers and therapeutic tar...