The Same, but Different: Shared Hallmarks and Divergent Drivers in Adult, Pediatric and Canine Glioma
Malignant gliomas are the most common primary brain tumors, with dismal outcomes. Pet dogs have been proposed as a valuable model for studying gliomas. Here, we compare spontaneously occurring gliomas from adult and pediatric human and canine patients, focusing on the tumor microenvironment (TME) and the canonical path...