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Dan-Qian Cheng

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Sep 2026

SIRT1-mediated deacetylation of TRIM21 promotes IRF5 degradation and restrains type I interferon signatures in Sjögren's disease.

INTRODUCTION Persistently activated type I interferon (IFN) signaling is a key factor in glandular dysfunction of Sjögren's disease(SjD), with elevated "type I interferon signatures" observed in both peripheral blood and salivary gland tissues of affected patients. However, the intrinsic mechanisms suppressing this res...

Yu-Hao Xuan, Dan-Qian Cheng, Qi Xi et al. · 0 citations

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