Dan-Ting Guo

Maslinic acid derivative induces the death of transitional bladder cancer cells through apoptosis and autophagy via the PI3K-AKT signaling pathway.

l-Phenylalanine and l-glutamine were conjugated with maslinic acid and 3-epi maslinic acid to generate 16 derivatives. Most of them exhibited higher cytotoxic activity than maslinic acid towards various tumour cell lines. Based on the results from the human apoptosis array and western blotting assays, derivative 7, a 2...