Insights into pyrazinone biosynthesis from biochemical and cryo-EM studies of the hybrid NRPS-PKS enzyme CorA
Hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) systems integrate peptide and polyketide biosynthetic logic to assemble complex natural products. CorA, a prototypical NRPS-PKS hybrid from the myxobacterium Corallococcus exiguus SDU70, is responsible for producing 5-alkylated pyrazinones, a family...