Author

Dandan Guo

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Open access Aug 2026

Topical Dunaliella salina-Derived Exosome Loaded with Methotrexate Alleviates Psoriasis-like Inflammation via STAT3-Dependent Th17/Treg Balance

Background: Methotrexate (MTX) is a well-established therapeutic agent for psoriasis owing to its anti-inflammatory and immunomodulatory effects. However, its clinical use is limited by insufficient local accumulation in skin lesions and the potential risk of systemic exposure. Dunaliella salina-derived exosome (DsEXO)...

Yi-Tong Yang, Dan-Dan Guo, Wei Chen et al. · Pharmaceutics · 0 citations

Review Open access Aug 2026

Engineered MSC-exosomes as CRISPR-Cas9 delivery vectors for precision immunotherapy

This review presents a comprehensive analysis of strategies for engineering MSC-Exos as delivery vehicles for CRISPR-Cas9, with emphasis on cargo-loading methodologies and surface modifications that enable targeting specific immune cell populations.

Dan-Dan Guo, Wei Zhang, Wen-Bo Dou et al. · Frontiers in Bioengineering... · 0 citations