Open access
Oct 2026
FAP adipogenesis drives early spinal muscle loss in dysferlinopathy and reveals a therapeutic target
Early degeneration of spinal muscles, rather than limb muscles, emerges as a key driver of gait dysfunction in dysferlinopathy, revealing axial muscle pathology as a previously overlooked disease feature and identifying GSK3 inhibition as a promising therapeutic strategy.
Young Jae Moon, Nikki M. McCormack, Thomas Diehn et al.
· EMBO Molecular Medicine · 0 citations