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Author

Daniel C. Nelson

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Open access Aug 2026

Directed evolution of the bacteriophage endolysin PlyC reveals a charge-mediated mechanism of thermal stabilization

This validated directed evolution methodology can now be expanded to other endolysins and bacteriolytic enzymes for the purpose of increasing their thermal stability, thereby improving their practical utility as an antimicrobial biologic.

Ryan D. Heselpoth, Daniel C. Nelson · 0 citations

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