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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Daniel Fernández

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Open access Oct 2026

Development of Next-Generation ALDH1B1 Inhibitors with Enhanced Pharmacological and Functional Properties

ALDH1B1 is a mitochondrial aldehyde dehydrogenase required for the survival of stem-like colorectal and pancreatic cancer cells. Isoform-selective guanidinyl antagonists of aldehyde dehydrogenases (IGUANAs) have been developed for ALDH1B1, and here we describe structure−activity relationship (SAR) studies of three sc...

A. Tarhan, Zhi-Ping Feng, Daniel Fernández et al. · 0 citations
Open access Sep 2026

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

It is shown that plasma IgG reactivity to this region remains rare, even after repeated antigen exposure, and kinetic and avidity constraints governing neutralization at the HR2 stem helix and position hr2.016 as a resilient therapeutic candidate.

Virginia Crivelli, Concetta Guerra, M. Abernathy et al. · 0 citations

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