Daniel J. Moore

Transcriptionally distinct atypical B cell populations contribute to insulin autoreactivity and show differential activation, isotype switching, and somatic hypermutation in early-stage type 1 diabetes individuals

Autoreactive B cells must escape immune tolerance mechanisms to drive autoimmune disease, potentially through alternative paths to memory and antibody-secreting cell formation. “Atypical” B cells represent one such alternative pathway and are expanded in several human autoimmune diseases. Atypical B cells display pheno...