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Author

Daniel J. Rader

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Open access Sep 2026

The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study.

RATIONALE & OBJECTIVE Angiopoietin-like proteins (ANGPTL) 3 and 4 modulate lipoprotein metabolism through inhibition of lipases. Reduced activity of ANGPTL3 and ANGPTL4 improves kidney function in mice. This study aimed to investigate the causal relationships of ANGPTLs and their lipase targets with chronic kidney dise...

Guo-Yi Yang, David Y. Zhang, Clara J. Fischman et al. · 0 citations

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