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Author

Daniel L. Kiss

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Open access Aug 2026

Codon optimality modulates cellular stress and innate immune responses triggered by exogenous RNAs

Despite advancements in RNA sequence design, evidence regarding the preferential use of synonymous codons on cellular stress and innate immune responses is lacking. To this end, we developed a new codon optimality formula to re-engineer the coding sequences of three luciferase reporters. We demonstrate that mRNAs enric...

Chotiwat Seephetdee, Nada Bejar, Kathrina D Castillo et al. · 0 citations
Open access Aug 2026

Kinetic Control of Nuclear-encoded Mitochondrial mRNA Localization and Local Translation

These experiments and modeling suggest that the process of local translation at the OMM is kinetically controlled by the cell, and reveal an unappreciated mechanism by which active transport of RNAs enables cells to modulate their translation within minutes through RNA localization control.

Surbhi Sharma, Xue-Mei Wang, Steven Nguyen et al. · 0 citations

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