Daniel Nietlispach

Uncoupling of the allosteric signalling network in the β1-adrenergic receptor by a negative allosteric modulator

Allosteric modulation is a fundamental aspect of G protein-coupled receptor (GPCR) regulation where molecules that bind to alternative sites outside the orthosteric pocket alter agonist-induced signalling responses. The advantages of allosteric modulators over traditional orthosteric agonists have positioned them a...