Author

Daniela E. Aust

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Open access Oct 2026

α7 integrin co-regulates chromatin accessibility and gene expression in HPV-negative head and neck cancer

Epigenetic regulation and gene transcription are dynamically modulated by extracellular signals, including focal adhesions; however, the role of integrins in these processes remains poorly understood. In this study in HPV-negative head and neck squamous cell carcinoma, (HNSCC), we combined investigations in physiologic...

Olegs Borodins, A. Vehlow, Katrin Sameith et al. · Signal Transduction and Targ... · 0 citations

Open access Sep 2026

TIGIT+ CD4+ T Cell Enrichment in Colorectal Liver Metastases Is Associated with Shorter Survival

Simple Summary Colorectal cancer frequently spreads to the liver, where the local immune environment may limit the effectiveness of immunotherapy. We examined immune cells from blood, non-tumor liver tissue, and colorectal cancer liver metastases. Freshly isolated immune cells from 17 patients were analyzed, and a sepa...

Janusz von Renesse, Jakob Langsdorf, Elisabeth Kalb et al. · Cancers · 0 citations

Open access Sep 2026

A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions

Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture systems using patient-derived materials have advanc...

Julius Thyen, V. A. Sioson, Daniel Haak et al. · npj Precision Oncology · 0 citations