Background Frailty is characterized by declining homeostatic reserves and increased vulnerability to stressors, and has been associated with cognitive decline and dementia. Objective To examine the relationship between frailty, Alzheimer's disease (AD) biomarkers, and cognitive performance in individuals with mild cogn...
Manuela Pintus, M. Valletta, L. Sacchi et al.· Journal of Alzheimer's Disea...· 0 citations
Factor analysis indicated that DTI-ALPS clustered with MA and ODI rather than forming a distinct factor, suggesting that DTI-ALPS primarily reflects WM diffusion dispersion and heterogeneity rather than glymphatic flow in the context of neurodegeneration.
L. Sacchi, Giovanni Farruggio, Giorgio Bocca et al.· bioRxiv· 1 citation
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
CP enlargement is associated with reduced DTI-ALPS and greater WML burden, but the contribution of glymphatic impairment remains uncertain, and alternative mechanisms may contribute to these findings.
L. Sacchi, Valentina Veronesi, Giorgio Bocca et al.· Journal of Alzheimer's Disea...· 0 citations
Findings support the presence of a compartment-specific reorganization of inflammatory signalling during AD progression and highlight the potential of MDEVs as accessible peripheral biomarkers of neuroinflammatory processes in AD.
Chiara Bianchessi, M. Serpente, E. Ferri et al.· GeroScience· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
