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Author

Daniela Kramer

2 papers indexed here

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Open access Oct 2026

H2A.J is an epigenetic driver of IL-17-associated inflammation in TH17 cells and keratinocytes

Psoriasis is a common autoinflammatory disease driven by excessive IL-17 expression. While the pathomechanism of the disease has been revealed, epigenetic factors contributing to psoriasis are less well understood. Here, we investigated the role of the poorly studied histone variant H2A.J in psoriasis. We found that H2...

T. Kübelbeck, Anna Stastny, N. Beumer et al. · 0 citations
Open access Sep 2026

KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation

Inflammatory monocytes are increasingly recognized as key amplifiers of psoriasis, yet the epigenetic drivers of their pathogenic signature remain unclear. The mechanisms linking epigenetic regulation to metabolic reprogramming in monocyte-driven inflammation in psoriasis are poorly defined. We examined the expression...

Aman Damara, Najla Abassi, D. Mihoc et al. · 0 citations

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