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Author

D. Mattei

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2 papers indexed here

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Open access Oct 2026

Parkinson’s disease genetic risk converges on Lewy body pathology-associated microglial states

Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...

Raphael Kübler, Daniele Mattei, J. O. Narcís et al. · 0 citations
Open access Sep 2026

Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson’s Disease Spectrum

The role of peripheral immunity in Parkinson's disease (PD) remains incompletely understood. Here, we performed paired single-cell RNA sequencing (scRNA-seq) and T-cell receptor (TCR) profiling of 630k peripheral blood mononuclear cells (PBMCs) from 168 donors spanning idiopathic and genetic PD, prodromal PD, and healt...

Mikaela Rosen, J. Majos, Daniele Mattei et al. · 0 citations

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