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Author

Danish Sayed

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Aug 2026

RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy.

RUNX1-driven EndoMT represents a central mechanism linking LMNA mutations to fibrotic remodelling in LMNA cardiomyopathy and supports endothelial transcriptional reprogramming and RUNX1 signalling as potential therapeutic targets in fibrotic cardiomyopathy.

David Wu, D. Tripathi, Amit Manhas et al. · 1 citation
Open access Aug 2026

Sirt1 inhibits the recruitment of RNA polymerase II to metabolic gene promoter during pressure overload through competition with the preinitiation complex on Sub1.

Sirt1 impairs metabolic gene transcription during PO by competitively inhibiting Sub1-mediated recruitment of GTFs and PIC formation, which contributes to the metabolic disturbance and may represent a maladaptive component of the heart failure phenotype.

Shin-ichi Oka, Youssef Mourad, Samta Veera et al. · 0 citations

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