Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches.
Melanoma differentiation-associated protein 5 (MDA5), encoded by IFIH1, is a cytosolic double-stranded RNA (dsRNA) sensor. Mutation of IFIH1 resulting in MDA5 deficiency causes immune dysfunction and predisposition to specific respiratory viral pathogens due to the inability of innate immune system to detect viral dsRN...