Dao-Qi You

Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma

Intratumor heterogeneity and plasticity contribute to resistance, as coexisting tumor cell states exhibit non-overlapping drug sensitivities and divergent responses to therapy. Combination therapy design thus requires identifying vulnerabilities of treatment-persistent populations and measuring state-specific drug ef...