Open access
Aug 2026
SEI1 complex silences p53 to drive myeloma progression
Summary SEI1 is overexpressed in multiple myeloma and correlates with poor prognosis. In this study, we identify SEI1 as a crucial driver of myeloma pathogenesis through a previously unrecognized mechanism: transcriptional inactivation of the tumor suppressor p53. Mechanistically, SEI1 forms a transcriptional complex w...
Rui Chen, Rui Liu, Zhi-Hong Fang et al.
· iScience · 0 citations