Tripled-Stranded Antisense Oligonucleotide for Biomarker-Activated Suppression of Essential Genes.
Conditional activation of antisense oligonucleotides (ASOs) is a promising strategy for selective suppression of cancer cells without affecting normal cells. In this study, we developed a tripled-stranded ASO (tsASO) that is rendered inactive through complexation with two additional oligonucleotides. The key innovation...