Open access
Oct 2026
Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.
Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...
A. Sadanandam, A. O'Farrell, I. Miller et al.
· Cancer Cell · 1 citation