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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Darren P. Wallace

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Open access Sep 2026

CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD.

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are caused by mutations in PKD1, which reduce polycystin-1 (PC1) levels below a critical functional threshold. Normalizing PC1 dosage mitigates disease progression; therefore, we sought to develop a CRISPR activation (CRISPRa) strategy to transcriptiona...

Anubhav Chakraborty, Meekha M. Varghese, Darren P. Wallace et al. · 0 citations
Open access Aug 2026

Dysregulated Ferritin and Iron Homeostasis in Autosomal Dominant Polycystic Kidney Disease.

A disruption in ferritin handling and iron homeostasis in PKD is demonstrated, suggesting altered iron trafficking promotes localized oxidative stress and fibrosis contributing to disease progression.

Nicole Sommer, Sagine Placide, Elizabeth Weatherly et al. · 0 citations
Open access Jul 2026

Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease.

Findings reveal that autophagy in MFs is a previously unrecognized driver of cyst expansion and fibrosis in ADPKD and targeting MF-specific autophagy or its upstream regulators may represent a therapeutic strategy to limit cyst growth and fibrosis in ADPKD.

Abeda Jamadar, Viji Remadevi, Meekha M. Varghese et al. · 0 citations

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