Dastin Misiaszek

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SARCOPENIC OBESITY IN THE ERA OF INCRETIN-BASED THERAPIES: DIAGNOSTIC CHALLENGES, THE RISK OF MUSCLE MASS LOSS, AND PREVENTION STRATEGIES

Introduction and purpose. Sarcopenic obesity (SO) is defined by the coexistence of excess adiposity and reduced muscle mass and function and is associated with disability, frailty, cardiometabolic disease, and increased mortality. This review aims to summarize current evidence on the definition and diagnosis of SO, ass...

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The role of physical activity in secondary prevention after myocardial infarction

Physical activity (PA) is one of the fundamental elements of secondary prevention after acute coronary syndrome (ACS) and myocardial infarction (MI), as well as a key component of cardiac rehabilitation (CR). Available evidence indicates that higher levels of PA are associated with lower mortality, reduced risk of recu...

RECENT ADVANCES IN AUTOPHAGY AND VESICLE TRAFFICKING IN PANCREATIC DISEASES: MOLECULAR MECHANISMS AND SELECTIVE AUTOPHAGY PATHWAYS

This review summarizes recent advances in autophagy, selective autophagy, and vesicle trafficking in pancreatic physiology and disease and focuses on the dual role of autophagy, which can support cellular protection and organelle quality control, but also contribute to pathology when dysregulated.

Exercise-induced BDNF signaling mediates neuroplasticity in depression

Background.Major depressive disorder (MDD) is increasingly recognized as a disorder of impaired neuroplasticity. Brain-derived neurotrophic factor (BDNF) plays a central role in neuronal survival, synaptic plasticity, and antidepressant mechanisms [1–4]. Physical exercise has emerged as an effective non-pharmacological...