Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of APA in brain cell types and its contribution to genetic disease have rem...
Jiu-Hong Nan, Carles A. Boix, Shao-Hui Shi et al.· Nature Genetics· 0 citations
Alzheimer’s disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that mod...
Er-Ming Wang, Bo-Er Xie, Minghui Wang et al.· bioRxiv· 0 citations
A post-spatial profiling workflow that combines the Xenium platform with iterative indirect immunofluorescence imaging (4i) on formalin-fixed paraffin-embedded (FFPE) human brain tissue to capture key pathological features for Alzheimer’s disease (AD) and facilitate cell segmentation is reported.
Berke Karaahmet, Tsering Lama, An-Qi Wang et al.· bioRxiv· 0 citations
These findings provide a cell-type-resolved and ancestry-aware atlas of genetically regulated expression in the human prefrontal cortex and illustrate how single-nucleus transcriptomics can sharpen gene discovery and therapeutic target prioritization for complex brain disorders.
S. Venkatesh, Roman Kosoy, Zhen-Yi Wu et al.· Nature· 7 citations
Comparative subcellular proteomics applied to dorsolateral prefrontal cortex from 75 individuals spanning the Alzheimer’s disease-resilience spectrum is developed, modelling protein localisation across disease.
Helen A. Jolly, Paula Seghers, Kaleah Balcomb et al.· bioRxiv· 0 citations
This study provides the first whole human brain map of AD pathology-associated transcriptomic signals, and exposes cell type, region, and cortex layer specific vulnerabilities.
Anwesha Bhattacharya, C. Savignac, Liam Hodgson et al.· bioRxiv· 0 citations
This study identifies molecular signatures of systemic aging rooted in bone marrow HSPCs and suggests that dysregulated ribosomal protein gene expression is an under‐appreciated hallmark of hematopoietic stem cell aging.
Roger Atanga, Saurav Mallik, Soumita Seth et al.· Advances in Biology· 0 citations
It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.
Donghoon Lee, James M. Vicari, Christian Porras et al.· Nature Genetics· 1 citation
It was found that AD was characterized by altered microglial composition and rewiring of intercellular communication, including disease-specific signaling pathways and distinct interaction hubs.
Loren dos Santos, R. Vialle, Natacha Comandante-Lou et al.· bioRxiv· 0 citations
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